Neuropathy Biopsy Testing Lab Services

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Skin biopsy for Epidermal Nerve Fiber Density (ENFD) testing is a reliable tool for diagnosing small-fiber neuropathy (SFN).
The sensitivity of skin biopsy in diagnosing small fiber neuropathy has been reported to be 88%.
This is in comparison to 54% for the clinical examination, and 49% for quantitative sensory testing (1).
The specificity of the test is 98% (1).
Many diseases are associated with SFN such as diabetic neuropathy, alcoholic neuropathy, medication-induced neuropathy, fibromyalgia, and others -> see our education module!
Skin biopsy is a safe procedure with minimal discomfort that allows somatic fibers carrying temperature and pain sensation to be differentiated from autonomic fibers.
Loss of epidermal nerve fibers correlates with increased severity of neuropathy and a higher risk of developing neuropathic pain.
Skin nerve fibers are able to regenerate, and their regrowth rate could be a marker of early axonal damage in patients at risk of developing peripheral neuropathy.
A skin biopsy can be repeated in close proximity to a previous biopsy in order to assess the progression of neuropathy and the response to neuroprotective treatments and can be used as a measure of outcome in clinical trials.

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