Cancer Risk & Genetic Carrier Screening

Hereditary or Predisposition Cancer Genomics

Genetic Testing looks for specific inherited changes (mutations) in a person’s genetic make-up.
Genetic mutations can have harmful, beneficial, neutral, or uncertain effects on health.
Mutations that are harmful may increase a person’s chance, or risk, of developing a disease such as cancer.
Inherited mutations mutations are thought to play a role in 5-10% of all cancers.
These particular disease states are known as hereditary cancers and proper genetic testing can be used to determine an individuals risk.

Some people inherit mutation(s) in the germline, potentially allowing for the cancers associated with the same to be passed on.
There are two classes of cellular genes: oncogenes and tumor suppressor genes.
Often, multiple genetic mutations in a single individual are responsible for the development of hereditary cancers.

Cancer is a disorder in which normal control of cell growth is lost—causing abnormal proliferation of the effected cells.
Inherited genetic mutations can increase a person’s risk of developing cancer through a variety of contrivances, depending on the functions of the mutated gene. Mutations in genes that control the repair of damaged DNA and cell growth are particularly likely to be associated with an increased risk of cancer.


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