Autonomic Nervous System Testing


TM-Flow is the only available device  for the early detection and monitoring of neuropathic and vascular complications resulting from chronic diseases, such as Diabetes.

TM-Flow is a Medical Device Data System measuring vital signs such as heart rate, SpO2%, blood pressure, and Galvanic Skin Response.

The mathematical analysis of the vital signs provides markers of  autonomic neuropathy and vascular dysfunction 
The vital sign measurements use 3 technologies: SweatC, LD-Oxy and TM-ABI.
In addition to  our audited quality system, the performance of the TM-Flow System has been validated by:
1- The background of the system’s technologies published in peer reviews:
2-  Clinical studies which compare the accuracy of the TM-Flow  System Markers to the:

        – Gold standard for Ankle Brachial Indices (ABI) measurements using the Doppler method
        – Gold standard of Insulin resistance assessment – Hyperinsulinemic Euglycemic Clamp  (HEC)
        – Oral Glucose Tolerance Test (OGTT)
        – Coronary angiography
        – Diabetic Neuropathy Symptoms (DNS) score
Vascular function Assessment :  
Peripheral circulation from the Photoplethysmography (PTG) analysis
Arterial stiffness and Ankle Brachial Indices from the Volume plethysmography analysis
ANS Assessment :
Sudomotor Function Markers.
Heart rate variability Analysis  (HRV)
Cardiac Autonomic Reflex Tests  –  Valsalva Ratio, E/I Ratio and K30/15 Ratio  


ANS-1 system integrates 3 technologies based on Galvanic skin response ,  photoplethysmography analysis and oscillometry to assess the Autonomic Nervous System and Peripheral circulation.

ANS-1 System manages the Autonomic Nervous System battery of tests recommended by the American Academy of Neurology since 1996, and the Cardiovascular Autonomic Neuropathy Subcommittee of the Toronto Consensus Panel on Diabetic Neuropathy, for assessing the Autonomic Nervous System.
Autonomic testing is recommended for all patients with type 2 diabetes at the time of the diagnosis, and 5 years after diagnosis in individuals with type 1 diabetes.
( Boulton et al., 2005;Tesfaye et al., 2010;Spallone et al., 2011; Bernardi et al.,2011.)
Vascular function Assessment 
Peripheral circulation  from
Photoplethysmography (PTG) analysis​​
​Brachial blood pressure
ANS Assessment :
Sudomotor markers
​Heart rate variability Analysis and Cardiac Autonomic Reflex Tests(  Valsalva Ratio, E/I Ratio, K30/15 Ratio and Systolic response difference while standing).​​


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